| Product description : |
Product Information
Product Name: Griseofulvin
Cas No.: 126-07-8
Molecular Formula: C17H17ClO6
Molecular Weight: 352.77
Uses:
Griseofulvin is used to treat skin infections such as jock itch, athlete's foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails.
Specification:
Test items
Specifications (BP2011 /EP7.0)
Description
A white or yellow white microfine powder
Identification
A: IR
B:Colour test (a white-red colour develops)
Acidity
Not more than 1.0ml of 0.02M sodium hydroxide is required.
Solubility
Practically insoluble in water,freely soluble in dimethyl formamide and in tetrachloroethane,slightly soluble in ethanol and in methanol.
Specific optical rotation
Calculated with reference to the dried substance +354°~+364°
Particle size
95% no more than 5um(larger particles which may occasionally exceed 30um)
Melting point
It melts at about 220℃
Appearance of solution
The solution is clear
Not more intensely coloured than reference solution Y4
Related substances:
Dechologriseofulvin
Less than 0.60
Dehydrogriseofulvin
Less than 0.15
Substances soluble in light petroleum
NMT 0.20%
Loss on drying
NMT 1.00%
Sulphated ash
NMT 0.20%
Abnormal toxicity
Five mice orals,none of the mice dies within 48h
Assay(anhydrous substance)
97.0% to 102.0% |
| Synonyms : |
grisovin;7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2R,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione;(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohexane]-3,4'-dione;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R-trans)-;(+)-Griseofulvin; |
